There’s a lot to criticise Mark Zuckerberg about currently but I’m really not liking the way people are falling back on his personality. I’ve zero reasons to defend him and there is certainly a ‘punching up’ defence about being gratuitously mean about a figure in power. However, I know most reasonable people would instantly spot that using Jewish and anti-semitic stereotypes to mock him would be an appalling thing to do – precisely because doing so hurts others and perpetuates attitudes, beliefs and prejudices that hurt others.
The same goes for mocking him in ways that parallel the way autistic people (or people who aren’t autistic but who maybe mocked for being so) are mocked. It feeds negative stereotypes and normalises prejudices.
Note that the alt-right have been using both anti-semitic tropes and anti-autistic tropes about Mark Zuckerberg for years now. That’s often a good indication of what NOT to do. The issue isn’t that Zuckerberg might seem odd but that his company is trampling all over people’s privacy. He’s a rich arsehole and that would still be true if he was charismatically charming.